Publications
*indicates corresponding author
†indicates equal contributions
2026
In vitro induction of human germinal centre B-cells.
D Priest, MF Demir, W Ise, JB Wing*.
Science Immunology, Vol 11, Issue 123.
Protocol for live cell barcoding and immunophenotyping of human hematological malignancies using cytometry by time of flight.
T Mikami, JB Wing, J Takita, I Kato*.
STAR protocols, 7 (3).
Heterogeneity of Memory B cells in Human Blood.
D Priest, JB Wing*.
International Immunology, dxag006.
CAR-T cells with the CD38-CD73-Tim-3-HLA-DR+ phenotype predict the efficacy of tisagenlecleucel as a treatment for B cell precursor ALL.
T Mikami, I Kato*, M Anais Llamas-Covarrubias, H Hiramatsu, Y Uchihara , T Mitsuyoshi, T Kitawaki, S Saida, K Umeda, S Ogawa, A Takaori-Kondo, JB Wing†, J Takita†*.
Cell Reports Medicine 102576
Mycobacterial α-glucans hijack dectin-1 to facilitate intracellular bacterial survival.
S Torigoe, S Salie, R Keeton, B Aylan, BJ Appelmelk, DL Williams, DW Lowman, T Sugiki, S Matsumoto, A Kawano, S Mizuno, K Matsuo, JN Søndergaard, JB Wing, M A. Höft, R Shoesmith, M Ndengane, AK Coussens, JA Willment, MG Gutierrez, JC Hoving, S Yamasaki*, GD Brown*.
Science Immunology. Vol 11, Issue 115.
2025
Single cell suppression profiling of human regulatory T cells.
J Søndergaard*, J Tulyeu, D Priest, S Sakaguchi, JB Wing*.
Nature communications, 16 (1), 2025.
Human precursor T follicular regulatory cells are primed for differentiation into mature Tfr and disrupted during severe infections.
J Tulyeu, JN. Søndergaard, DG. Priest, T Ebihara, H Matsumoto, MA. Llamas-Covarrubias, M Imai, S Esaki, S Iwasaki, A Morita, S Yamazaki, S Sakaguchi, JB. Wing*
Science Advances 11 (39), eadv6939.
Optimized Detection and Inference of immune cell type Names in scRNA-seq data.
J Tulyeu†, D Priest†, JB. Wing*, JN Søndergaard*.
The Journal of Immunology 214 (11), 3131-3142.
Multi-omics analysis identifies an M-MDSC-like immunosuppressive phenotype in lineage-switched AML with KMT2A rearrangement.
T Mikami, Itaru Kato*, A Nishimura, M Eguchi-Ishimae, T Kamitori, K Tasaka, H Kubota, T Isobe, Y Uchihara, Y Namikawa, S Hamada, S Tsujimoto, S Inoue, T Hamabata, K Izawa, T Miyamura, D Tomizawa, T Imamura, H Toyoda, M Eguchi, H Goto, S Ogawa, M Takagi, JB Wing†, Junko Takita†*.
Nature communications, 16 (1), 7955.
Assessing human Treg suppression at single-cell resolution using mass cytometry.
JN Søndergaard*, J Tulyeu, D Priest, S Sakaguchi, and JB. Wing*.
Bio-Protocol, 15 (16). 2025 Aug 20;15(16):e5424.
Multifaceted profiling of virus-specific CD8 T cells reveals distinct immune signatures against cytomegalovirus infection states during pregnancy.
A Taguchi, F Misumi, S Teraguchi, T Nagamatsu, S Sakakibara, T Otani, M Ichinose, D Priest, K Nakajima, J Nakamura, R Sawada, T Suzutani, T Ikeda, Y Nagura, T Iriyama, D Okuzaki, H Okazaki, JB Wing, Y Hirota, Y Osuga.
iScience, 28(5), 2025.
2024
Non-classical CD45RBlo memory B-cells are the majority of circulating antigen-specific B-cells following mRNA vaccination and COVID-19 infection
D Priest, T Ebihara, J Tulyeu, J Søndergaard, S Sakakibara, F Sugihara, S Nakao, Y Togami, J Yoshimura, H Ito, S Onishi, A Muratsu, Y Mitsuyama, H Ogura, J Oda, D Okuzaki, H Matsumoto*, JB Wing*.
Nature Communications, 15 (1), 6811
Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses
H Metwally, MM Elbrashy, T Ozawa, K Okuyama, JT White, J Tulyeu, JN Søndergaard, JB Wing, A Muratsu, H Matsumoto, M Ikawa, H Kishi, Ichiro Taniuchi, T Kishimoto.
Proceedings of the National Academy of Sciences. 121, 17.
Quantification of escape from X chromosome inactivation with single-cell omics data reveals heterogeneity across cell types and tissues.
Yoshihiko Tomofuji, [148 authors including JB Wing], Yuko Harada.
Cell Genomics 4 (8)
CTLA-4+ 1 innate lymphoid cells restrain interleukin-23 mediated inflammation.
A Ahmed, AM Joseph, J Zhou, V Horn, J Uddin , M Lyu, J Goc, JRI Live Cell Bank, R Sockolow, JB. Wing, E Vivier, S Sakaguchi, GF. Sonnenberg.
Nature 630, 976–983
Clonal landscape of autoantibody-secreting plasmablasts in COVID-19 patients.
S Sakakibara, Y-C Liu, M Ishikawa, R Edahiro, Y Shirai, S Haruna, M Hussien, Z Xu, S Li, Y Yamaguchi, T Murakami, T Morita, Y Kato, H Hirata, Y Takeda, F Sugihara, Y Naito, D Motooka, C-Y Tsai, C Ono, Y Matsuura, JB Wing, H Matsumoto, H Ogura, M Okada, A Kumanogoh, Y Okada, DM Standley, H Kikutani, D Okuzaki.
Life Science Alliance, 7 (12)
2023
A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity
M Okamoto, M Sasai, A Kuratani, D Okuzaki, M Arai, JB. Wing, S Sakaguchi, M Yamamoto
Cell Reports 42 (7), 112813
R Morita, R Kubota-Koketsu, X Lu, T Sasaki, EE Nakayama, Y Liu, ...
iScience 26 (5)
R Edahiro, Y Shirai, Y Takeshima, S Sakakibara, Y Yamaguchi, ...
Nature genetics, 1-15
K Minohara, M Imai, T Matoba, JB Wing, H Shime, M Odanaka, R Uraki, ...
Cancer Science 114 (4), 1256
Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex
T Shirai, A Nakai, E Ando, J Fujimoto, S Leach, T Arimori, D Higo, ...
Science Immunology 8 (81), eadc9324
JN Søndergaard, J Tulyeu, R Edahiro, Y Shirai, Y Yamaguchi, ...
Proceedings of the National Academy of Sciences 120 (4), e2217902120
Identification of a unique subset of tissue-resident memory CD4+ T cells in Crohn’s disease
T Yokoi, M Murakami, T Kihara, S Seno, M Arase, JB Wing, ...
Proceedings of the National Academy of Sciences 120 (1), e2204269120
出版物
Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells
Y Yamaguchi, Y Kato, R Edahiro, JN Søndergaard, T Murakami, S Amiya, ...
JCI insight 7 (22)
Regulatory T lymphocytes in cancer immunity
D Adeegbe, J Barbi, J Wing
Frontiers in Immunology 13, 1065570
Using Mass Cytometry to Address Tfh and Tfr Heterogeneity
JB Wing, S Sakaguchi
T-Follicular Helper Cells: Methods and Protocols, 47-57
DOCK2 is involved in the host genetics and biology of severe COVID-19
H Namkoong, R Edahiro, T Takano, H Nishihara, Y Shirai, K Sonehara, ...
Nature 609 (7928), 754-760
K Shibata, C Motozono, M Nagae, T Shimizu, E Ishikawa, D Motooka, ...
Nature communications 13 (1), 6948
T Mikami, I Kato, JB Wing, H Ueno, K Tasaka, K Tanaka, H Kubota, ...
Cancer Science 113 (1), 41-52
2021
MSJ Lee, T Inoue, W Ise, J Matsuo-Dapaah, JB Wing, B Temizoz, ...
Journal of Experimental Medicine 219 (2), e20211336
Isolation and Characterization of Both Human and Mouse Tfh/Tfr Cells
J Tulyeu, JN Søndergaard, S Sakaguchi, JB Wing
Current Protocols 1 (11), e283
EP Mimitou, CA Lareau, KY Chen, AL Zorzetto-Fernandes, Y Hao, ...
Nature biotechnology 39 (10), 1246-1258
Arid5a promotes immune evasion by augmenting tryptophan metabolism and chemokine expression
G Parajuli, M Tekguc, JB Wing, A Hashimoto, D Okuzaki, T Hirata, ...
Cancer immunology research 9 (8), 862-876
M Tekguc, JB Wing, M Osaki, J Long, S Sakaguchi
Proceedings of the National Academy of Sciences 118 (30), e2023739118
CTLA-4 expression by B-1a B cells is essential for immune tolerance
Y Yang, X Li, Z Ma, C Wang, Q Yang, M Byrne-Steele, R Hong, Q Min, ...
Nature Communications 12 (1), 525
2020
Dynamics of effector and naïve Regulatory T cells throughout pregnancy
N Shigeta, K Kumasawa, A Tanaka, JB Wing, H Nakamura, S Sakaguchi, ...
Journal of Reproductive Immunology 140, 103135
Control of foreign Ag‐specific Ab responses by Treg and Tfr
JB Wing, EL Lim, S Sakaguchi
Immunological reviews 296 (1), 104-119
Regulatory T cells and human disease
S Sakaguchi, N Mikami, JB Wing, A Tanaka, K Ichiyama, N Ohkura
Annual review of immunology 38, 541-566
2019
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch, A Acs, D Adam, S Adam‐Klages, ...
European journal of immunology 49 (10), 1457-1973
Human FOXP3+ regulatory T cell heterogeneity and function in autoimmunity and cancer
JB Wing, A Tanaka, S Sakaguchi
Immunity 50 (2), 302-316
D Ha, A Tanaka, T Kibayashi, A Tanemura, D Sugiyama, JB Wing, EL Lim, ...
Proceedings of the National Academy of Sciences 116 (2), 609-618
Control of regulatory T cells by co-signal molecules
JB Wing, C Tay, S Sakaguchi
Co-signal Molecules in T Cell Activation: Immune Regulation in Health and Disease, 179